So not sure some of the stuff I am about to say has been mentioned, but there are a couple of things that I would like to see updated in maybe 10.7 or even if somebody could fix it in 10.6. Also, these are all written from the perspective of playing it on a PC/laptop so not for anything like building your own cabinet (just wanted to clear up any confusion so in case if somebody started reading they weren't like "Wait a sec, I never had that happen on my cabinet") but here goes
1) I would like the options menu (when you press Q) to be a bit more UI friendly and just overall have a better look and feel like you get when you are playing FX3 or PA, plus have some more options like FX3 where you can select stuff like resume game, restart games, options (for sound etc), so that way it would be easier to just navigate in and out of tables easier than having to remember a bunch of hot keys
2) When I pause the game and go out of it by using alt+tab, I would like to be able to just smoothly transition in and out of the game to another screen without having to leave the game and then end up having the game freeze and just shut down VPX and restart all over again
3) Just for fun, I would like to have maybe something like FX3 where when you add new tables, it's more or less a cleaner UI as well instead of just clicking on a table in your folder and the game start up. I know that might be a bit of a challenge to pull something like that off but hey, we all can dream.
So that is about the only major things I can think of. Have a great day 